Association between low birth weight and septal heart defect in multiple birth offspring
Code: G-12840
Authors: Hassan Mottaghi Moghaddam Shahri, Fatemeh Rezvanifard ©, Sina Afzoon ℗
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Abstract:
Background
Congenital heart defect (CHD) is one of the most usual congenital malformations and is associated with almost one-third of all significant congenital anomalies. Out of all types of congenital heart disease (CHD), VSD and ASD contributed to 51% of the cases, and this amount has been increasing through time. Low birth weight (LBW) is a known comorbidity of congenital heart disease (CHD). This study aimed to discern the association between septal heart defect and LBW in multiple-birth offspring.
Methods
This retrospective cohort study was performed on 828 patients, covering all multiple-birth offspring referred to the pediatric cardiology clinic of Imam Reza Hospital from 2003 to 2022. These patients were split into two groups, normal birth weight (NBW) (between 2500 and 4000 g), and LBW (less than 2500 g), and then investigated for septal heart defects in each group.
Results
The 828 patients analyzed in the study included 266 (32.1%) with a NBW and 562 (67.9%) with a LBW. The septal heart defects in the NBW and LBW patients were 14.7% and 12.6%, without any significant difference between the two groups (p=0.42). The NBW group had a 2.8% frequency rate of ASD, 10.1% VSD, and 0.7% AVSD; the LBW group had a 3.8% frequency rate of ASD, 11.7% VSD, and 0.8% AVSD. There was no difference in the comparison of clinical information, gender, prematurity, and type of delivery in patients with septal heart defects between the two groups.
Conclusions
An analysis of multiple-birth offspring indicated although LBW was common in multiple gestations, the LBW did not increase the risk of septal heart defect.
Keywords
Septal Heart Defect, Low Birth Weight, Multiple Birth Offspring